The Uptake and Metabolism of Amino Acids, and Their Unique Role in the Biology of Pathogenic Trypanosomatids

Trypanosoma brucei, as well as Trypanosoma cruzi and more than 20 species of the genus Leishmania, form a group of flagellated protists that threaten human health. These organisms are transmitted by insects that, together with mammals, are their natural hosts. This implies that during their life cyc...

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Main Authors:	Letícia Marchese, Janaina de Freitas Nascimento, Flávia Silva Damasceno, Frédéric Bringaud, Paul A. M. Michels, Ariel Mariano Silber
Format:	Article
Language:	English
Published:	MDPI AG 2018-04-01
Series:	Pathogens
Subjects:	amino acid metabolism amino acid uptake bioenergetics stress management autophagy host-parasite interaction
Online Access:	http://www.mdpi.com/2076-0817/7/2/36

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spelling	doaj-a6ebb9117ffe4d4289f371ac4417cc862020-11-24T22:51:09ZengMDPI AGPathogens2076-08172018-04-01723610.3390/pathogens7020036pathogens7020036The Uptake and Metabolism of Amino Acids, and Their Unique Role in the Biology of Pathogenic TrypanosomatidsLetícia Marchese0Janaina de Freitas Nascimento1Flávia Silva Damasceno2Frédéric Bringaud3Paul A. M. Michels4Ariel Mariano Silber5Laboratory of Biochemistry of Tryps—LaBTryps, Department of Parasitology, Institute for Biomedical Sciences, University of Sao Paulo, Av. Lineu Prestes, 1374, São Paulo 05508-000, SP, BrazilLaboratory of Biochemistry of Tryps—LaBTryps, Department of Parasitology, Institute for Biomedical Sciences, University of Sao Paulo, Av. Lineu Prestes, 1374, São Paulo 05508-000, SP, BrazilLaboratory of Biochemistry of Tryps—LaBTryps, Department of Parasitology, Institute for Biomedical Sciences, University of Sao Paulo, Av. Lineu Prestes, 1374, São Paulo 05508-000, SP, BrazilLaboratoire de Microbiologie Fondamentale et Pathogénicité (MFP), Université de Bordeaux, CNRS UMR-5234, 146, rue Léo Saignat, Zone Nord, Bâtiment 3A, 33076 Bordeaux, FranceCentre for Immunity, Infection and Evolution and Centre for Translational and Chemical Biology, School of Biological Sciences, Ashworth Laboratories, Charlotte Auerbach Road, The University of Edinburgh, Edinburgh EH9 3FL, UKLaboratory of Biochemistry of Tryps—LaBTryps, Department of Parasitology, Institute for Biomedical Sciences, University of Sao Paulo, Av. Lineu Prestes, 1374, São Paulo 05508-000, SP, BrazilTrypanosoma brucei, as well as Trypanosoma cruzi and more than 20 species of the genus Leishmania, form a group of flagellated protists that threaten human health. These organisms are transmitted by insects that, together with mammals, are their natural hosts. This implies that during their life cycles each of them faces environments with different physical, chemical, biochemical, and biological characteristics. In this work we review how amino acids are obtained from such environments, how they are metabolized, and how they and some of their intermediate metabolites are used as a survival toolbox to cope with the different conditions in which these parasites should establish the infections in the insects and mammalian hosts.http://www.mdpi.com/2076-0817/7/2/36amino acid metabolismamino acid uptakebioenergeticsstress managementautophagyhost-parasite interaction
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Letícia Marchese Janaina de Freitas Nascimento Flávia Silva Damasceno Frédéric Bringaud Paul A. M. Michels Ariel Mariano Silber
spellingShingle	Letícia Marchese Janaina de Freitas Nascimento Flávia Silva Damasceno Frédéric Bringaud Paul A. M. Michels Ariel Mariano Silber The Uptake and Metabolism of Amino Acids, and Their Unique Role in the Biology of Pathogenic Trypanosomatids Pathogens amino acid metabolism amino acid uptake bioenergetics stress management autophagy host-parasite interaction
author_facet	Letícia Marchese Janaina de Freitas Nascimento Flávia Silva Damasceno Frédéric Bringaud Paul A. M. Michels Ariel Mariano Silber
author_sort	Letícia Marchese
title	The Uptake and Metabolism of Amino Acids, and Their Unique Role in the Biology of Pathogenic Trypanosomatids
title_short	The Uptake and Metabolism of Amino Acids, and Their Unique Role in the Biology of Pathogenic Trypanosomatids
title_full	The Uptake and Metabolism of Amino Acids, and Their Unique Role in the Biology of Pathogenic Trypanosomatids
title_fullStr	The Uptake and Metabolism of Amino Acids, and Their Unique Role in the Biology of Pathogenic Trypanosomatids
title_full_unstemmed	The Uptake and Metabolism of Amino Acids, and Their Unique Role in the Biology of Pathogenic Trypanosomatids
title_sort	uptake and metabolism of amino acids, and their unique role in the biology of pathogenic trypanosomatids
publisher	MDPI AG
series	Pathogens
issn	2076-0817
publishDate	2018-04-01
description	Trypanosoma brucei, as well as Trypanosoma cruzi and more than 20 species of the genus Leishmania, form a group of flagellated protists that threaten human health. These organisms are transmitted by insects that, together with mammals, are their natural hosts. This implies that during their life cycles each of them faces environments with different physical, chemical, biochemical, and biological characteristics. In this work we review how amino acids are obtained from such environments, how they are metabolized, and how they and some of their intermediate metabolites are used as a survival toolbox to cope with the different conditions in which these parasites should establish the infections in the insects and mammalian hosts.
topic	amino acid metabolism amino acid uptake bioenergetics stress management autophagy host-parasite interaction
url	http://www.mdpi.com/2076-0817/7/2/36
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The Uptake and Metabolism of Amino Acids, and Their Unique Role in the Biology of Pathogenic Trypanosomatids

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