Piperlongumine Induces Apoptosis and Synergizes with Doxorubicin by Inhibiting the JAK2-STAT3 Pathway in Triple-Negative Breast Cancer

Piperlongumine Induces Apoptosis and Synergizes with Doxorubicin by Inhibiting the JAK2-STAT3 Pathway in Triple-Negative Breast Cancer

Triple-negative breast cancer (TNBC) lacks major effective target molecules and chemotherapy remains the current main treatment. However, traditional chemotherapy drugs, such as doxorubicin (DOX), cause serious side effects and have a poor prognosis. Piperlongumine (PL), a natural alkaloid, has show...

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Bibliographic Details
Main Authors: Di Chen, Yangmin Ma, Peiqi Li, Meng Liu, Yuan Fang, Jiejie Zhang, Bilin Zhang, Yuyu Hui, Yue Yin
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Molecules
Subjects:
triple-negative breast cancer
piperlongumine
doxorubicin
apoptosis
JAK2
STAT3
Online Access:https://www.mdpi.com/1420-3049/24/12/2338

Internet

https://www.mdpi.com/1420-3049/24/12/2338

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