MicroRNA-27 Inhibits Autophagy and Promotes Proliferation of Multiple Myeloma Cells by Targeting the NEDD4/Notch1 Axis

MicroRNA-27 Inhibits Autophagy and Promotes Proliferation of Multiple Myeloma Cells by Targeting the NEDD4/Notch1 Axis

Multiple myeloma (MM) is a malignant tumor disease that seriously affects the health of patients. Previous studies have shown the crucial role of autophagy in the development of MM. Therefore, the study aimed to study the effect of miR-27 on autophagy in MM via NEDD4/Notch1 axis. RT-qPCR or western...

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Bibliographic Details
Main Authors: Feifei Che, Jiao Chen, Chunqian Wan, Xiaobing Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Oncology
Subjects:
miR-27
NEDD4
Notch1
autophagy
multiple myeloma
ubiquitination
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.571914/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2020.571914/full

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