Sustained Release of Lidocaine from Solvent-Free Biodegradable Poly[(d,l)-Lactide-co-Glycolide] (PLGA): In Vitro and In Vivo Study

Sustained Release of Lidocaine from Solvent-Free Biodegradable Poly[(d,l)-Lactide-co-Glycolide] (PLGA): In Vitro and In Vivo Study

Local anesthetics are commonly used for pain relief by regional nerve blocking. In this study, we fabricated solvent-free biodegradable pellets to extend the duration of lidocaine release without any significant local or systemic toxicity levels. To manufacture the pellets, poly[(d,l)-lactide-co-gly...

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Bibliographic Details
Main Authors: Yi-Chuan Kau, Chia-Chih Liao, Ying-Chi Chen, Shih-Jung Liu
Format: Article
Language:English
Published: MDPI AG 2014-09-01
Series:Materials
Subjects:
poly[(d,l)-lactide-co-glycolide] (PLGA)
lidocaine
sustained release
biodegradable pellets
Online Access:http://www.mdpi.com/1996-1944/7/9/6660

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http://www.mdpi.com/1996-1944/7/9/6660

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