Chemotherapy-induced recruitment of myeloid-derived suppressor cells abrogates efficacy of immune checkpoint blockade

Chemotherapy-induced recruitment of myeloid-derived suppressor cells abrogates efficacy of immune checkpoint blockade

Background & aims: Immune checkpoint blockade (ICB) has been approved for treatment of hepatocellular carcinoma (HCC). However, many patients with advanced HCC are non-responders to ICB monotherapy. Cytotoxic chemotherapy has been proposed to modulate the tumor microenvironment (TME) and sen...

Full description

Bibliographic Details
Main Authors: Tsz Tung Kwong, Chi Hang Wong, Jing Ying Zhou, Alfred Sze Lok Cheng, Joseph Jao Yiu Sung, Anthony Wing Hung Chan, Stephen Lam Chan
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:JHEP Reports
Subjects:
Tumor microenvironment
Hepatocellular carcinoma
Chemotherapy
Myeloid-derived suppressor cell
Immune checkpoint blockade
Immunotherapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555920301580

Internet

http://www.sciencedirect.com/science/article/pii/S2589555920301580

Similar Items