Antibody-Directed Glucocorticoid Targeting to CD163 in M2-type Macrophages Attenuates Fructose-Induced Liver Inflammatory Changes

Antibody-Directed Glucocorticoid Targeting to CD163 in M2-type Macrophages Attenuates Fructose-Induced Liver Inflammatory Changes

Increased consumption of high-caloric carbohydrates contributes substantially to endemic non-alcoholic fatty liver disease in humans, covering a histological spectrum from fatty liver to steatohepatitis. Hypercaloric intake and lipogenetic effects of fructose and endotoxin-driven activation of liver...

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Bibliographic Details
Main Authors: Pia Svendsen, Jonas H. Graversen, Anders Etzerodt, Henrik Hager, Rasmus Røge, Henning Grønbæk, Erik I. Christensen, Holger J. Møller, Hendrik Vilstrup, Søren K. Moestrup
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
macrophages
glucocorticoid
inflammation
dexamethasone
antibody-drug conjugates
CD163
fructose
steatohepatitis
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050116301322

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http://www.sciencedirect.com/science/article/pii/S2329050116301322

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