Cell-free DNA captures tumor heterogeneity and driver alterations in rapid autopsies with pre-treated metastatic cancer

Cell-free DNA captures tumor heterogeneity and driver alterations in rapid autopsies with pre-treated metastatic cancer

It is currently unclear if cell-free DNA samples from metastatic cancers are as informative as tissue ones for cancer profiling. Here the authors show that cell-free DNA samples from rapid autopsies capture clonal and subclonal alterations of metastatic tumours and reveal more driver alterations tha...

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Bibliographic Details
Main Authors: Bernard Pereira, Christopher T. Chen, Lipika Goyal, Charlotte Walmsley, Christopher J. Pinto, Islam Baiev, Read Allen, Laura Henderson, Supriya Saha, Stephanie Reyes, Martin S. Taylor, Donna M. Fitzgerald, Maida Williams Broudo, Avinash Sahu, Xin Gao, Wendy Winckler, A. Rose Brannon, Jeffrey A. Engelman, Rebecca Leary, James R. Stone, Catarina D. Campbell, Dejan Juric
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-23394-4

Internet

https://doi.org/10.1038/s41467-021-23394-4

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