IgE-mediated mast cell activation promotes inflammation and cartilage destruction in osteoarthritis

IgE-mediated mast cell activation promotes inflammation and cartilage destruction in osteoarthritis

Osteoarthritis is characterized by articular cartilage breakdown, and emerging evidence suggests that dysregulated innate immunity is likely involved. Here, we performed proteomic, transcriptomic, and electron microscopic analyses to demonstrate that mast cells are aberrantly activated in human and...

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Bibliographic Details
Main Authors: Qian Wang, Christin M Lepus, Harini Raghu, Laurent L Reber, Mindy M Tsai, Heidi H Wong, Ericka von Kaeppler, Nithya Lingampalli, Michelle S Bloom, Nick Hu, Eileen E Elliott, Francesca Oliviero, Leonardo Punzi, Nicholas J Giori, Stuart B Goodman, Constance R Chu, Jeremy Sokolove, Yoshihiro Fukuoka, Lawrence B Schwartz, Stephen J Galli, William H Robinson
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-05-01
Series:eLife
Subjects:
osteoarthritis
mast cell
innate immunity
Online Access:https://elifesciences.org/articles/39905

Internet

https://elifesciences.org/articles/39905

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