IgE-mediated mast cell activation promotes inflammation and cartilage destruction in osteoarthritis
Osteoarthritis is characterized by articular cartilage breakdown, and emerging evidence suggests that dysregulated innate immunity is likely involved. Here, we performed proteomic, transcriptomic, and electron microscopic analyses to demonstrate that mast cells are aberrantly activated in human and...
Main Authors: | , , , , , , , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2019-05-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/39905 |