Reduced Susceptibility to Neuraminidase Inhibitors in Influenza B Isolate, Canada

Reduced Susceptibility to Neuraminidase Inhibitors in Influenza B Isolate, Canada

We identified an influenza B isolate harboring a Gly407Ser neuraminidase substitution in an immunocompromised patient in Canada before antiviral therapy. This mutation mediated reduced susceptibility to oseltamivir, zanamivir, and peramivir, most likely by preventing interaction with the catalytic A...

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Bibliographic Details
Main Authors: Yacine Abed, Clément Fage, Patrick Lagüe, Julie Carbonneau, Jesse Papenburg, Donald C. Vinh, Guy Boivin
Format: Article
Language:English
Published: Centers for Disease Control and Prevention 2019-04-01
Series:Emerging Infectious Diseases
Subjects:
influenza B
resistance
neuraminidase
Gly407Ser
oseltamivir
zanamivir
Online Access:https://wwwnc.cdc.gov/eid/article/25/4/18-1554_article

Internet

https://wwwnc.cdc.gov/eid/article/25/4/18-1554_article

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