Heterologous prime-boost regimens with a recombinant chimpanzee adenoviral vector and adjuvanted F4 protein elicit polyfunctional HIV-1-specific T-Cell responses in macaques.

Heterologous prime-boost regimens with a recombinant chimpanzee adenoviral vector and adjuvanted F4 protein elicit polyfunctional HIV-1-specific T-Cell responses in macaques.

HIV-1-specific CD4+ and CD8+ T lymphocytes are important for HIV-1 replication control. F4/AS01 consists of F4 recombinant fusion protein (containing clade B Gag/p24, Pol/RT, Nef and Gag/p17) formulated in AS01 Adjuvant System, and was shown to induce F4-specific polyfunctional CD4+ T-cell responses...

Full description

Bibliographic Details
Main Authors: Clarisse Lorin, Yannick Vanloubbeeck, Sébastien Baudart, Michaël Ska, Babak Bayat, Geoffroy Brauers, Géraldine Clarinval, Marie-Noëlle Donner, Martine Marchand, Marguerite Koutsoukos, Pascal Mettens, Joe Cohen, Gerald Voss
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4391709?pdf=render

Internet

http://europepmc.org/articles/PMC4391709?pdf=render

Similar Items