A RNA producing DNA hydrogel as a platform for a high performance RNA interference system

Interfering RNA have a range of therapeutic and research based applications, issues with delivery have made systems that make siRNA in situ of interest. Here, the author report on the creation of a DNA hydrogel with improved stability and transcription efficiency over plasmid DNA.

Bibliographic Details
Main Authors: Jaejung Song, Minhyuk Lee, Taeyoung Kim, Jeongkyeong Na, Yebin Jung, Gyoo Yeol Jung, Sungjee Kim, Nokyoung Park
Format: Article
Language:English
Published: Nature Publishing Group 2018-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06864-0