Defective angiogenesis in CXCL12 mutant mice impairs skeletal muscle regeneration

Defective angiogenesis in CXCL12 mutant mice impairs skeletal muscle regeneration

Abstract Background During muscle regeneration, the chemokine CXCL12 (SDF-1) and the synthesis of some specific heparan sulfates (HS) have been shown to be critical. CXCL12 activity has been shown to be heavily influenced by its binding to extracellular glycosaminoglycans (GAG) by modulating its pre...

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Bibliographic Details
Main Authors: David Hardy, Mylène Fefeu, Aurore Besnard, David Briand, Paméla Gasse, Fernando Arenzana-Seisdedos, Pierre Rocheteau, Fabrice Chrétien
Format: Article
Language:English
Published: BMC 2019-09-01
Series:Skeletal Muscle
Subjects:
Muscle stem cells
Endothelial cells
CXCL12
Heparan sulfates
Skeletal muscle
Regeneration
Online Access:http://link.springer.com/article/10.1186/s13395-019-0210-5

Internet

http://link.springer.com/article/10.1186/s13395-019-0210-5

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