Detection of DNA mismatch repair proteins in fresh human blood lymphocytes - towards a novel method for hereditary non-polyposis colorectal cancer (Lynch syndrome) screening

Detection of DNA mismatch repair proteins in fresh human blood lymphocytes - towards a novel method for hereditary non-polyposis colorectal cancer (Lynch syndrome) screening

<p>Abstract</p> <p>Background</p> <p>A broad population-based assay to detect individuals with Lynch Syndrome (LS) before they develop cancer would save lives and healthcare dollars via cancer prevention. LS is caused by a germline mutation in a DNA mismatch repair (MMR...

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Bibliographic Details
Main Authors: Ali Nawab, Boman Bruce M, Hassen Samar, Parker Marcie, Somerman Chandra, Ali-Khan Catts Zohra J, Ali Akhtar A, Fields Jeremy Z
Format: Article
Language:English
Published: BMC 2011-10-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Lynch Syndrome
Hereditary Cancer
MMR proteins
HNPCC
MLH1
MSH2
Lymphocytes
PHA treatment
Western blotting
Cell Culture
Online Access:http://www.jeccr.com/content/30/1/100

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http://www.jeccr.com/content/30/1/100

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