Elevated Mitochondrial Reactive Oxygen Species and Cellular Redox Imbalance in Human NADPH-Oxidase-Deficient Phagocytes

Elevated Mitochondrial Reactive Oxygen Species and Cellular Redox Imbalance in Human NADPH-Oxidase-Deficient Phagocytes

Chronic granulomatous disease (CGD) is caused by mutations in genes that encode the NADPH-oxidase and result in a failure of phagocytic cells to produce reactive oxygen species (ROS) via this enzyme system. Patients with CGD are highly susceptible to infections and often suffer from inflammatory dis...

Full description

Bibliographic Details
Main Authors: Martina Sundqvist, Karin Christenson, Halla Björnsdottir, Veronica Osla, Anna Karlsson, Claes Dahlgren, David P. Speert, Anders Fasth, Kelly L. Brown, Johan Bylund
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Immunology
Subjects:
chronic granulomatous disease
oxidative stress
reactive oxygen species
inflammation
cytokine
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01828/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01828/full

Similar Items