Regulation of lipid metabolism by obeticholic acid in hyperlipidemic hamsters

Regulation of lipid metabolism by obeticholic acid in hyperlipidemic hamsters

The farnesoid X receptor (FXR) plays critical roles in plasma cholesterol metabolism, in particular HDL-cholesterol (HDL-C) homeostasis. Obeticholic acid (OCA) is a FXR agonist being developed for treating various chronic liver diseases. Previous studies reported inconsistent effects of OCA on regul...

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Bibliographic Details
Main Authors: Bin Dong, Mark Young, Xueqing Liu, Amar Bahadur Singh, Jingwen Liu
Format: Article
Language:English
Published: Elsevier 2017-02-01
Series:Journal of Lipid Research
Subjects:
farnesoid X receptor
scavenger receptor class B type I
high density lipoprotein cholesterol
hepatocyte nuclear factor 4 α
low density lipoprotein receptor
sterol regulatory element-binding protein 2
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520314164

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http://www.sciencedirect.com/science/article/pii/S0022227520314164

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