Temporally Distinct Six2-Positive Second Heart Field Progenitors Regulate Mammalian Heart Development and Disease

Temporally Distinct Six2-Positive Second Heart Field Progenitors Regulate Mammalian Heart Development and Disease

The embryonic process of forming a complex structure such as the heart remains poorly understood. Here, we show that Six2 marks a dynamic subset of second heart field progenitors. Six2-positive (Six2+) progenitors are rapidly recruited and assigned, and their descendants are allocated successively t...

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Bibliographic Details
Main Authors: Zhengfang Zhou, Jingying Wang, Chaoshe Guo, Weiting Chang, Jian Zhuang, Ping Zhu, Xue Li
Format: Article
Language:English
Published: Elsevier 2017-01-01
Series:Cell Reports
Subjects:
Six1
Six2
Shh
cardiac outflow tract
persistent truncus arteriosus
PTA
common arterial trunk
tetralogy of Fallot
TOF
intrapericardial arterial trunk
second heart field
cardiac neural crest
progenitor
high-resolution episcopic microscopy
HREM
diphtheria toxin fragment A
DTA
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717300207

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http://www.sciencedirect.com/science/article/pii/S2211124717300207

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