Delta/Notch-Like EGF-Related Receptor (DNER) Is Not a Notch Ligand.

Delta/Notch-like EGF-related receptor (DNER) has been reported to act as a Notch ligand, despite lacking a Delta/Serrate/Lag (DSL) binding domain common to all other known ligands. The established Notch ligand Delta-like 1 (DLL1), but not DNER, activated Notch1 in a luciferase assay, prevented the d...

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Bibliographic Details
Main Authors: Maxwell Greene, Yongjie Lai, Kostandin Pajcini, Will Bailis, Warren S Pear, Eric Lancaster
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5021350?pdf=render