Delta/Notch-Like EGF-Related Receptor (DNER) Is Not a Notch Ligand.

Delta/Notch-Like EGF-Related Receptor (DNER) Is Not a Notch Ligand.

Delta/Notch-like EGF-related receptor (DNER) has been reported to act as a Notch ligand, despite lacking a Delta/Serrate/Lag (DSL) binding domain common to all other known ligands. The established Notch ligand Delta-like 1 (DLL1), but not DNER, activated Notch1 in a luciferase assay, prevented the d...

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Main Authors: Maxwell Greene, Yongjie Lai, Kostandin Pajcini, Will Bailis, Warren S Pear, Eric Lancaster
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5021350?pdf=render
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spelling doaj-a7260b3468154f0e8dadddaaaf7af2da2020-11-24T21:45:55ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01119e016115710.1371/journal.pone.0161157Delta/Notch-Like EGF-Related Receptor (DNER) Is Not a Notch Ligand.Maxwell GreeneYongjie LaiKostandin PajciniWill BailisWarren S PearEric LancasterDelta/Notch-like EGF-related receptor (DNER) has been reported to act as a Notch ligand, despite lacking a Delta/Serrate/Lag (DSL) binding domain common to all other known ligands. The established Notch ligand Delta-like 1 (DLL1), but not DNER, activated Notch1 in a luciferase assay, prevented the differentiation of myoblasts through Notch signaling, and bound Notch-fc in a cell-based assay. DNER is not a Notch ligand and its true function remains unknown.http://europepmc.org/articles/PMC5021350?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Maxwell Greene
Yongjie Lai
Kostandin Pajcini
Will Bailis
Warren S Pear
Eric Lancaster
spellingShingle Maxwell Greene
Yongjie Lai
Kostandin Pajcini
Will Bailis
Warren S Pear
Eric Lancaster
Delta/Notch-Like EGF-Related Receptor (DNER) Is Not a Notch Ligand.
PLoS ONE
author_facet Maxwell Greene
Yongjie Lai
Kostandin Pajcini
Will Bailis
Warren S Pear
Eric Lancaster
author_sort Maxwell Greene
title Delta/Notch-Like EGF-Related Receptor (DNER) Is Not a Notch Ligand.
title_short Delta/Notch-Like EGF-Related Receptor (DNER) Is Not a Notch Ligand.
title_full Delta/Notch-Like EGF-Related Receptor (DNER) Is Not a Notch Ligand.
title_fullStr Delta/Notch-Like EGF-Related Receptor (DNER) Is Not a Notch Ligand.
title_full_unstemmed Delta/Notch-Like EGF-Related Receptor (DNER) Is Not a Notch Ligand.
title_sort delta/notch-like egf-related receptor (dner) is not a notch ligand.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2016-01-01
description Delta/Notch-like EGF-related receptor (DNER) has been reported to act as a Notch ligand, despite lacking a Delta/Serrate/Lag (DSL) binding domain common to all other known ligands. The established Notch ligand Delta-like 1 (DLL1), but not DNER, activated Notch1 in a luciferase assay, prevented the differentiation of myoblasts through Notch signaling, and bound Notch-fc in a cell-based assay. DNER is not a Notch ligand and its true function remains unknown.
url http://europepmc.org/articles/PMC5021350?pdf=render
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