Pale body-like inclusion formation and neurodegeneration following depletion of 26S proteasomes in mouse brain neurones are independent of α-synuclein.

Pale body-like inclusion formation and neurodegeneration following depletion of 26S proteasomes in mouse brain neurones are independent of α-synuclein.

Parkinson's disease (PD) is characterized by the progressive degeneration of substantia nigra pars compacta (SNpc) dopaminergic neurones and the formation of Lewy bodies (LB) in a proportion of the remaining neurones. α-synuclein is the main component of LB, but the pathological mechanisms that...

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Bibliographic Details
Main Authors: Simon M L Paine, Glenn Anderson, Karen Bedford, Karen Lawler, R John Mayer, James Lowe, Lynn Bedford
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23382946/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23382946/?tool=EBI

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