Spinophilin modulates pain through suppressing dendritic spine morphogenesis via negative control of Rac1-ERK signaling in rat spinal dorsal horn

Spinophilin modulates pain through suppressing dendritic spine morphogenesis via negative control of Rac1-ERK signaling in rat spinal dorsal horn

Both spinophilin (SPN, also known as neurabin 2) and Rac1 (a member of Rho GTPase family) are believed to play key roles in dendritic spine (DS) remodeling and spinal nociception. However, how SPN interacts with Rac1 in the above process is unknown. Here, we first demonstrated natural existence of S...

Full description

Bibliographic Details
Main Authors: Jiang-Lin Wang, Yan Wang, Wei Sun, Yang Yu, Na Wei, Rui Du, Yan Yang, Ting Liang, Xiao-Liang Wang, Ce-Hua Ou, Jun Chen
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Neurobiology of Disease
Subjects:
Spinophilin
Rac1
ERK
Spinal dorsal horn
Dendritic spine
Pain
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996121000516

Internet

http://www.sciencedirect.com/science/article/pii/S0969996121000516

Similar Items