Clinical Activity of an hTERT-Specific Cancer Vaccine (Vx-001) in “Immune Desert” NSCLC

Clinical Activity of an hTERT-Specific Cancer Vaccine (Vx-001) in “Immune Desert” NSCLC

Background: Tumors can be separated into immunogenic/hot and non-immunogenic/cold on the basis of the presence of tumor-infiltrating lymphocytes (TILs), the expression of PD-L1 and the tumor mutation burden (TMB). In immunogenic tumors, TILs become unable to control tumor growth because their activi...

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Bibliographic Details
Main Authors: Ioannis S. Pateras, Athanasios Kotsakis, Margaritis Avgeris, Evangelia Baliou, Panagiotis Kouroupakis, Eleni Patsea, Vassilis Georgoulias, Jeanne Menez-Jamet, Jean-Pierre Kinet, Kostas Kosmatopoulos
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cancers
Subjects:
cancer vaccines
Vx-001
metastatic non-small cell lung cancer
immunologically cold tumors
tumor-infiltrating lymphocytes
granzyme B
Online Access:https://www.mdpi.com/2072-6694/13/7/1658

Internet

https://www.mdpi.com/2072-6694/13/7/1658

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