Neuroprotective effects of verbascoside against Alzheimer’s disease via the relief of endoplasmic reticulum stress in Aβ-exposed U251 cells and APP/PS1 mice

Neuroprotective effects of verbascoside against Alzheimer’s disease via the relief of endoplasmic reticulum stress in Aβ-exposed U251 cells and APP/PS1 mice

Abstract Background Endoplasmic reticulum (ER) stress is involved in the progression of Alzheimer’s disease (AD). Verbascoside (VB), an active phenylethanoid glycoside that was first isolated from Verbascum sinuatum (the wavyleaf mullein), possesses anti-inflammatory, antioxidative, and anti-apoptot...

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Bibliographic Details
Main Authors: Chunyue Wang, Xueying Cai, Ruochen Wang, Siyu Zhai, Yongfeng Zhang, Wenji Hu, Yizhi Zhang, Di Wang
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Journal of Neuroinflammation
Subjects:
Alzheimer’s disease
Verbascoside
Endoplasmic reticulum stress
Unfolded protein response
Aβ
Online Access:http://link.springer.com/article/10.1186/s12974-020-01976-1

Internet

http://link.springer.com/article/10.1186/s12974-020-01976-1

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