The Crimean-Congo Hemorrhagic Fever Virus NSm Protein is Dispensable for Growth In Vitro and Disease in Ifnar<sup>-/- </sup>Mice

The Crimean-Congo Hemorrhagic Fever Virus NSm Protein is Dispensable for Growth In Vitro and Disease in Ifnar<sup>-/- </sup>Mice

Crimean-Congo hemorrhagic fever virus (CCHFV) is a tri-segmented, tick-borne nairovirus that causes disease of ranging severity in humans. The CCHFV M segment encodes a complex glycoprotein precursor (GPC) that undergoes extensive endoproteolytic cleavage, giving rise to two structural proteins (Gn...

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Bibliographic Details
Main Authors: Stephen R. Welch, Florine E. M. Scholte, Jessica R. Spengler, Jana M. Ritter, JoAnn D. Coleman-McCray, Jessica R. Harmon, Stuart T. Nichol, Sherif R. Zaki, Christina F. Spiropoulou, Eric Bergeron
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Microorganisms
Subjects:
CCHF
Crimean-Congo hemorrhagic fever
reporter virus
fluorescent protein reporter
Ifnar-/-
Ifnar knockout mouse
Online Access:https://www.mdpi.com/2076-2607/8/5/775

Internet

https://www.mdpi.com/2076-2607/8/5/775

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