Calcium-Sensing Receptor Regulates Cytosolic [Ca2+] and Plays a Major Role in the Development of Pulmonary Hypertension

Calcium-Sensing Receptor Regulates Cytosolic [Ca2+] and Plays a Major Role in the Development of Pulmonary Hypertension

AbstractPulmonary arterial hypertension (PAH) is a progressive disease characterized by elevated pulmonary vascular resistance (PVR) leading to right heart failure and premature death. The increased PVR results in part from pulmonary vascular remodeling and sustained pulmonary vasoconstriction. Exce...

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Bibliographic Details
Main Authors: Kimberly A. Smith, Ramon J. Ayon, Haiyang Tang, Ayako Makino, Jason X.-J. Yuan
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-11-01
Series:Frontiers in Physiology
Subjects:
Pulmonary Artery
smooth muscle cells
G-protein-coupled receptor
pulmonary arterial hypertension
Ca2+-sensing receptor
Store-operated channels
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00517/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00517/full

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