DNA hydrolysing IgG catalytic antibodies: an emerging link between psychoses and autoimmunity
Abstract It is not uncommon to observe autoimmune comorbidities in a significant subset of patients with psychotic disorders, namely schizophrenia (SCZ) and bipolar disorder (BPD). To understand the autoimmune basis, the DNA abyzme activity mediated by serum polyclonal IgG Abs were examined in psych...
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doaj-a73844f9cf9e4529849057be02e8e7dd2021-03-11T11:47:49ZengNature Publishing Groupnpj Schizophrenia2334-265X2021-02-01711710.1038/s41537-021-00143-6DNA hydrolysing IgG catalytic antibodies: an emerging link between psychoses and autoimmunityRajendran Ramesh0Aparna Sundaresh1Ravi Philip Rajkumar2Vir Singh Negi3M. A. Vijayalakshmi4Rajagopal Krishnamoorthy5Ryad Tamouza6Marion Leboyer7A. S. Kamalanathan8Centre for BioSeparation Technology, Vellore Institute of Technology (VIT)Department of Clinical Immunology, Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER)Department of Psychiatry, Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER)Department of Clinical Immunology, Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER)Centre for BioSeparation Technology, Vellore Institute of Technology (VIT)Fondation FondaMentalFondation FondaMentalFondation FondaMentalCentre for BioSeparation Technology, Vellore Institute of Technology (VIT)Abstract It is not uncommon to observe autoimmune comorbidities in a significant subset of patients with psychotic disorders, namely schizophrenia (SCZ) and bipolar disorder (BPD). To understand the autoimmune basis, the DNA abyzme activity mediated by serum polyclonal IgG Abs were examined in psychoses patients, quantitatively, by an in-house optimized DNase assay. A similar activity exhibited by IgG Abs from neuropsychiatric-systemic lupus erythematosus (NP-SLE) patients was used as a comparator. Our data revealed that the IgG DNase activity of SCZ was close to that of NP-SLE and it was twofold higher than the healthy controls. Interestingly, the association between DNase activity with PANSS (positive, general and total scores) and MADRS were noted in a subgroup of SCZ and BPD patients, respectively. In our study group, the levels of IL-6 and total IgG in BPD patients were higher than SCZ and healthy controls, indicating a relatively inflammatory nature in BPD, while autoimmune comorbidity was mainly observed in SCZ patients.https://doi.org/10.1038/s41537-021-00143-6 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rajendran Ramesh Aparna Sundaresh Ravi Philip Rajkumar Vir Singh Negi M. A. Vijayalakshmi Rajagopal Krishnamoorthy Ryad Tamouza Marion Leboyer A. S. Kamalanathan |
spellingShingle |
Rajendran Ramesh Aparna Sundaresh Ravi Philip Rajkumar Vir Singh Negi M. A. Vijayalakshmi Rajagopal Krishnamoorthy Ryad Tamouza Marion Leboyer A. S. Kamalanathan DNA hydrolysing IgG catalytic antibodies: an emerging link between psychoses and autoimmunity npj Schizophrenia |
author_facet |
Rajendran Ramesh Aparna Sundaresh Ravi Philip Rajkumar Vir Singh Negi M. A. Vijayalakshmi Rajagopal Krishnamoorthy Ryad Tamouza Marion Leboyer A. S. Kamalanathan |
author_sort |
Rajendran Ramesh |
title |
DNA hydrolysing IgG catalytic antibodies: an emerging link between psychoses and autoimmunity |
title_short |
DNA hydrolysing IgG catalytic antibodies: an emerging link between psychoses and autoimmunity |
title_full |
DNA hydrolysing IgG catalytic antibodies: an emerging link between psychoses and autoimmunity |
title_fullStr |
DNA hydrolysing IgG catalytic antibodies: an emerging link between psychoses and autoimmunity |
title_full_unstemmed |
DNA hydrolysing IgG catalytic antibodies: an emerging link between psychoses and autoimmunity |
title_sort |
dna hydrolysing igg catalytic antibodies: an emerging link between psychoses and autoimmunity |
publisher |
Nature Publishing Group |
series |
npj Schizophrenia |
issn |
2334-265X |
publishDate |
2021-02-01 |
description |
Abstract It is not uncommon to observe autoimmune comorbidities in a significant subset of patients with psychotic disorders, namely schizophrenia (SCZ) and bipolar disorder (BPD). To understand the autoimmune basis, the DNA abyzme activity mediated by serum polyclonal IgG Abs were examined in psychoses patients, quantitatively, by an in-house optimized DNase assay. A similar activity exhibited by IgG Abs from neuropsychiatric-systemic lupus erythematosus (NP-SLE) patients was used as a comparator. Our data revealed that the IgG DNase activity of SCZ was close to that of NP-SLE and it was twofold higher than the healthy controls. Interestingly, the association between DNase activity with PANSS (positive, general and total scores) and MADRS were noted in a subgroup of SCZ and BPD patients, respectively. In our study group, the levels of IL-6 and total IgG in BPD patients were higher than SCZ and healthy controls, indicating a relatively inflammatory nature in BPD, while autoimmune comorbidity was mainly observed in SCZ patients. |
url |
https://doi.org/10.1038/s41537-021-00143-6 |
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