Reprogramming the Local Lymph Node Microenvironment Promotes Tolerance that Is Systemic and Antigen Specific

Reprogramming the Local Lymph Node Microenvironment Promotes Tolerance that Is Systemic and Antigen Specific

Many experimental therapies for autoimmune diseases, such as multiple sclerosis (MS), aim to bias T cells toward tolerogenic phenotypes without broad suppression. However, the link between local signal integration in lymph nodes (LNs) and the specificity of systemic tolerance is not well understood....

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Bibliographic Details
Main Authors: Lisa H. Tostanoski, Yu-Chieh Chiu, Joshua M. Gammon, Thomas Simon, James I. Andorko, Jonathan S. Bromberg, Christopher M. Jewell
Format: Article
Language:English
Published: Elsevier 2016-09-01
Series:Cell Reports
Subjects:
lymph node
immune tolerance
biomaterial
autoimmunity
microparticle
regulatory T cell
vaccine
nanoparticle
CNS
multiple sclerosis
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471631097X

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http://www.sciencedirect.com/science/article/pii/S221112471631097X

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