Regulatory Role of Hexokinase 2 in Modulating Head and Neck Tumorigenesis

Regulatory Role of Hexokinase 2 in Modulating Head and Neck Tumorigenesis

To support great demand of cell growth, cancer cells preferentially obtain energy and biomacromolecules by glycolysis over mitochondrial oxidative phosphorylation (OxPhos). Among all glycolytic enzymes, hexokinase (HK), a rate-limiting enzyme at the first step of glycolysis to catalyze cellular gluc...

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Bibliographic Details
Main Authors: Wan-Chun Li, Chien-Hsiang Huang, Yi-Ta Hsieh, Tsai-Ying Chen, Li-Hao Cheng, Chang-Yi Chen, Chung-Ji Liu, Hsin-Ming Chen, Chien-Ling Huang, Jeng-Fan Lo, Kuo-Wei Chang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Oncology
Subjects:
head and neck cancer
hexokinase 2
cellular malignancy
metabolic shift
therapeutic efficacy
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00176/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.00176/full

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