Myosin with hypertrophic cardiac mutation R712L has a decreased working stroke which is rescued by omecamtiv mecarbil

Myosin with hypertrophic cardiac mutation R712L has a decreased working stroke which is rescued by omecamtiv mecarbil

Hypertrophic cardiomyopathies (HCMs) are the leading cause of acute cardiac failure in young individuals. Over 300 mutations throughout β-cardiac myosin, including in the motor domain, are associated with HCM. A β-cardiac myosin motor mutation (R712L) leads to a severe form of HCM. Actin-gliding mot...

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Bibliographic Details
Main Authors: Aaron Snoberger, Bipasha Barua, Jennifer L Atherton, Henry Shuman, Eva Forgacs, Yale E Goldman, Donald A Winkelmann, E Michael Ostap
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-02-01
Series:eLife
Subjects:
single molecule
cardiac myosin
optical trapping
optical tweezers
hypertrophic cardiomyopathy
omecamtiv mecarbil
Online Access:https://elifesciences.org/articles/63691

Internet

https://elifesciences.org/articles/63691

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