Evolutionary Significance of the Neuroendocrine Stress Axis on Vertebrate Immunity and the Influence of the Microbiome on Early-Life Stress Regulation and Health Outcomes

Evolutionary Significance of the Neuroendocrine Stress Axis on Vertebrate Immunity and the Influence of the Microbiome on Early-Life Stress Regulation and Health Outcomes

Stress is broadly defined as the non-specific biological response to changes in homeostatic demands and is mediated by the evolutionarily conserved neuroendocrine networks of the hypothalamus-pituitary-adrenal (HPA) axis and the sympathetic nervous system. Activation of these networks results in tra...

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Bibliographic Details
Main Authors: Van A. Ortega, Emily M. Mercer, Gerald F. Giesbrecht, Marie-Claire Arrieta
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Microbiology
Subjects:
cortisol
inflammation
gut-brain axes
HPA axis
immunity
pediatrics
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.634539/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2021.634539/full

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