Molecular Mechanism of the Antiproliferative Activity of Short Immunostimulating dsRNA

Molecular Mechanism of the Antiproliferative Activity of Short Immunostimulating dsRNA

Small double-stranded RNAs with certain sequence motifs are able to interact with pattern-recognition receptors and activate the innate immune system. Recently, we identified a set of short double-stranded 19-bp RNA molecules with 3-nucleotide 3′-overhangs that exhibited pronounced antiproliferative...

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Bibliographic Details
Main Authors: Mikhail I. Zharkov, Marina A. Zenkova, Valentin V. Vlassov, Elena L. Chernolovskaya
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Oncology
Subjects:
immunostimulating dsRNA
antiproliferative activity
gene silencing
shRNA
pattern recognition receptors
PKR
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.01454/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2019.01454/full

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