Synthesis, biological evaluation, molecular docking and in silico ADMET screening studies of novel isoxazoline derivatives from acridone

A series of new acridone derivatives from isoxazoline (2a-l) were synthesized via 1,3-dipolar cycloaddition reaction between a variety of aryl nitrile oxides and N-allyl acridones using simple and efficient methods. This is the first ever green protocol to synthesize novel isoxazolines derivatives f...

Full description

Bibliographic Details
Main Authors: Mohammed Aarjane, Siham Slassi, Adib Ghaleb, Bouchra Tazi, Amina Amine
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Arabian Journal of Chemistry
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535221000721