Neuropathic Pain Induced Alterations in the Opioidergic Modulation of a Descending Pain Facilitatory Area of the Brain

Opioids play a major role at descending pain modulation but the effects of neuropathic pain on the brain opioidergic system remain understudied. Since descending facilitation is enhanced during neuropathic pain, we studied the opioidergic modulation of the dorsal reticular nucleus (DRt), a medullary...

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Bibliographic Details
Main Authors: Ana Rita Costa, Paulina Carvalho, Gunnar Flik, Steven P. Wilson, Carlos Reguenga, Isabel Martins, Isaura Tavares
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Cellular Neuroscience
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Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00287/full