Dynamics of Expression of Programmed Cell Death Protein-1 (PD-1) on T Cells After Allogeneic Hematopoietic Stem Cell Transplantation

Dynamics of Expression of Programmed Cell Death Protein-1 (PD-1) on T Cells After Allogeneic Hematopoietic Stem Cell Transplantation

Immune exhaustion contributes to treatment failure after allogeneic hematopoietic stem cell transplantation (HSCT) for hematological malignancies. Immune checkpoint blockade, including programmed cell death protein-1 (PD-1) blockade, is a promising strategy to improve the antitumor effect of allogen...

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Bibliographic Details
Main Authors: Federico Simonetta, Amandine Pradier, Carine Bosshard, Stavroula Masouridi-Levrat, Carole Dantin, Aikaterini Koutsi, Yordanka Tirefort, Eddy Roosnek, Yves Chalandon
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Immunology
Subjects:
PD-1
checkpoint inhibitors
HSCT
transplantation
exhaustion
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01034/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01034/full

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