Sumoylation Protects Against β-Synuclein Toxicity in Yeast

Sumoylation Protects Against β-Synuclein Toxicity in Yeast

Aggregation of α-synuclein (αSyn) plays a central role in the pathogenesis of Parkinson’s disease (PD). The budding yeast Saccharomyces cerevisiae serves as reference cell to study the interplay between αSyn misfolding, cytotoxicity and post-translational modifications (PTMs). The synuclein family i...

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Bibliographic Details
Main Authors: Blagovesta Popova, Alexandra Kleinknecht, Patricia Arendarski, Jasmin Mischke, Dan Wang, Gerhard H. Braus
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Molecular Neuroscience
Subjects:
beta-synuclein
Parkinson’s disease
sumoylation
posttranslational modification
yeast
proteasome
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2018.00094/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2018.00094/full

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