Elevated levels of plasma symmetric dimethylarginine and increased arginase activity as potential indicators of cardiovascular comorbidity in rheumatoid arthritis

Elevated levels of plasma symmetric dimethylarginine and increased arginase activity as potential indicators of cardiovascular comorbidity in rheumatoid arthritis

Abstract Background Rheumatoid arthritis (RA) patients are at high risk of developing cardiovascular disease (CVD). In RA, chronic inflammation may lead to endothelial dysfunction, an early indicator of CVD, owing to diminished nitric oxide (NO) production. Because l-arginine is the sole precursor o...

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Bibliographic Details
Main Authors: Unnikrishnan M. Chandrasekharan, Zeneng Wang, Yuping Wu, W. H. Wilson Tang, Stanley L. Hazen, Sihe Wang, M. Elaine Husni
Format: Article
Language:English
Published: BMC 2018-06-01
Series:Arthritis Research & Therapy
Subjects:
Rheumatoid arthritis
l-arginine
Dimethylarginines
Arginase
Nitric oxide
Online Access:http://link.springer.com/article/10.1186/s13075-018-1616-x

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http://link.springer.com/article/10.1186/s13075-018-1616-x

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