A double-blind placebo-controlled trial of minocycline on translocator protein distribution volume in treatment-resistant major depressive disorder

A double-blind placebo-controlled trial of minocycline on translocator protein distribution volume in treatment-resistant major depressive disorder

Abstract Gliosis is implicated in the pathophysiology of many neuropsychiatric diseases, including treatment-resistant major depressive disorder (TRD). Translocator protein total distribution volume (TSPO VT), a brain marker mainly reflective of gliosis in disease, can be measured using positron emi...

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Bibliographic Details
Main Authors: Sophia Attwells, Elaine Setiawan, Pablo M. Rusjan, Cynthia Xu, Stephen J. Kish, Neil Vasdev, Sylvain Houle, Apitharani Santhirakumar, Jeffrey H. Meyer
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-021-01450-3

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https://doi.org/10.1038/s41398-021-01450-3

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