The Length of the Expressed 3′ UTR Is an Intermediate Molecular Phenotype Linking Genetic Variants to Complex Diseases

The Length of the Expressed 3′ UTR Is an Intermediate Molecular Phenotype Linking Genetic Variants to Complex Diseases

In the last decades, genome-wide association studies (GWAS) have uncovered tens of thousands of associations between common genetic variants and complex diseases. However, these statistical associations can rarely be interpreted functionally and mechanistically. As the majority of the disease-associ...

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Bibliographic Details
Main Authors: Elisa Mariella, Federico Marotta, Elena Grassi, Stefano Gilotto, Paolo Provero
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Genetics
Subjects:
human genetic variants
alternative polyadenylation
quantitative trait loci (QTL)
whole-genome sequencing (WGS)
RNA sequencing (RNA-Seq)
genome-wide association studies (GWAS)
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.00714/full

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https://www.frontiersin.org/article/10.3389/fgene.2019.00714/full

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