Interactive calculator for operating characteristics of phase I cancer clinical trials using standard 3+3 designs

Among various Phase I clinical trial designs, rule-based standard 3 + 3 designs are the most widely utilized for their simplicity and robustness. It is necessary to define crucial operating characteristics of a Phase I clinical trial before it starts. Based on the assumed probability of dose limitin...

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Bibliographic Details
Main Authors: Zhengjia Chen, Youyun Zheng, Zhibo Wang, Michael Kutner, Walter J. Curran, Jeanne Kowalski
Format: Article
Language:English
Published: Elsevier 2018-12-01
Series:Contemporary Clinical Trials Communications
Online Access:http://www.sciencedirect.com/science/article/pii/S2451865418301017