Expression of antibody fragments in Saccharomyces cerevisiae strains evolved for enhanced protein secretion

Expression of antibody fragments in Saccharomyces cerevisiae strains evolved for enhanced protein secretion

Abstract Monoclonal antibodies, antibody fragments and fusion proteins derived thereof have revolutionized the practice of medicine. Major challenges faced by the biopharmaceutical industry are however high production costs, long processing times and low productivities associated with their producti...

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Bibliographic Details
Main Authors: Yanyan Wang, Xiaowei Li, Xin Chen, Jens Nielsen, Dina Petranovic, Verena Siewers
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Microbial Cell Factories
Subjects:
Pharmaceutical proteins
Saccharomyces cerevisiae
Protein secretion capacity
RNA-seq analysis
Online Access:https://doi.org/10.1186/s12934-021-01624-0

Internet

https://doi.org/10.1186/s12934-021-01624-0

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