An apoA-I mimetic peptibody generates HDL-like particles and increases alpha-1 HDL subfraction in mice

An apoA-I mimetic peptibody generates HDL-like particles and increases alpha-1 HDL subfraction in mice

The aim of this study is to investigate the capability of an apoA-I mimetic with multiple amphipathic helices to form HDL-like particles in vitro and in vivo. To generate multivalent helices and to track the peptide mimetic, we have constructed a peptibody by fusing two tandem repeats of 4F peptide...

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Bibliographic Details
Main Authors: Shu-Chen Lu, Larissa Atangan, Ki Won Kim, Michelle M. Chen, Renee Komorowski, Carolyn Chu, Joon Han, Sylvia Hu, Wei Gu, Murielle Véniant, Minghan Wang
Format: Article
Language:English
Published: Elsevier 2012-04-01
Series:Journal of Lipid Research
Subjects:
apolipoprotein AI
atherosclerosis
ATP binding cassette transporter A1
cholesterol efflux
4F peptide
high density lipoprotein
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520405589

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http://www.sciencedirect.com/science/article/pii/S0022227520405589

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