Astrocytic Insulin-Like Growth Factor-1 Protects Neurons Against Excitotoxicity

Astrocytic Insulin-Like Growth Factor-1 Protects Neurons Against Excitotoxicity

BackgroundExogenous insulin like growth factor-1 (IGF-1) is known to be neuroprotective in animal models with brain insults, while it can also cause hyperexcitability in rodents. In this regard, the role of endogenous IGF-1 in brain responses to brain insults like excitotoxicity, a common pathology...

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Bibliographic Details
Main Authors: Wei Chen, Bin He, Wusong Tong, Jinsong Zeng, Ping Zheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
insulin-like growth factor-1
kainic acid
excitotoxicity
hyperphosphorylated tau
astrocytes
neurons
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00298/full

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https://www.frontiersin.org/article/10.3389/fncel.2019.00298/full

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