BRAFV600E mutation impinges on gut microbial markers defining novel biomarkers for serrated colorectal cancer effective therapies

BRAFV600E mutation impinges on gut microbial markers defining novel biomarkers for serrated colorectal cancer effective therapies

Abstract Background Colorectal cancer (CRC) harboring BRAF V600E mutation exhibits low response to conventional therapy and poorest prognosis. Due to the emerging correlation between gut microbiota and CRC carcinogenesis, we investigated in serrated BRAF V600E cases the existence of a peculiar fecal...

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Bibliographic Details
Main Authors: Nadia Trivieri, Riccardo Pracella, Maria Grazia Cariglia, Concetta Panebianco, Paola Parrella, Alberto Visioli, Fabrizio Giani, Amata Amy Soriano, Chiara Barile, Giuseppe Canistro, Tiziana Pia Latiano, Lucia Dimitri, Francesca Bazzocchi, Dario Cassano, Angelo L. Vescovi, Valerio Pazienza, Elena Binda
Format: Article
Language:English
Published: BMC 2020-12-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Serrated human BRAF V600E colorectal carcinoma (CRC)
Gut microbiota
CRC biology and biomarkers
BRAF V600E CRC non-invasive diagnosis
Anti-BRAF V600E CRC patient-tailored strategies
Online Access:https://doi.org/10.1186/s13046-020-01801-w

Internet

https://doi.org/10.1186/s13046-020-01801-w

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