A deletion of IDUA exon 10 in a family of Golden Retriever dogs with an attenuated form of mucopolysaccharidosis type I

A deletion of IDUA exon 10 in a family of Golden Retriever dogs with an attenuated form of mucopolysaccharidosis type I

Abstract Background Mucopolysaccharidosis type I (MPS‐I) is a lysosomal storage disorder caused by a deficiency of the enzyme α‐l‐iduronidase, leading to accumulation of undegraded dermatan and heparan sulfates in the cells and secondary multiorgan dysfunction. In humans, depending upon the nature o...

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Bibliographic Details
Main Authors: Kiterie M. E. Faller, Alison E. Ridyard, Rodrigo Gutierrez‐Quintana, Angie Rupp, Celia Kun‐Rodrigues, Tatiana Orme, Karen L. Tylee, Heather J. Church, Rita Guerreiro, Jose Bras
Format: Article
Language:English
Published: Wiley 2020-09-01
Series:Journal of Veterinary Internal Medicine
Subjects:
Hurler
iduronidase
lysosomal storage disease
Scheie
Online Access:https://doi.org/10.1111/jvim.15868

Internet

https://doi.org/10.1111/jvim.15868

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