Predictability of polygenic risk score for progression to dementia and its interaction with APOE ε4 in mild cognitive impairment

Predictability of polygenic risk score for progression to dementia and its interaction with APOE ε4 in mild cognitive impairment

Abstract Background The combinatorial effect of multiple genetic factors calculated as a polygenic risk score (PRS) has been studied to predict disease progression to Alzheimer’s disease (AD) from mild cognitive impairment (MCI). Previous studies have investigated the performance of PRS in the predi...

Full description

Bibliographic Details
Main Authors: Jung-Min Pyun, Young Ho Park, Keon-Joo Lee, SangYun Kim, Andrew J. Saykin, Kwangsik Nho, for the Alzheimer’s Disease Neuroimaging Initiative
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Translational Neurodegeneration
Subjects:
Polygenic risk score
Mild cognitive impairment
Alzheimer’s disease
Disease progression
APOE ε4
Online Access:https://doi.org/10.1186/s40035-021-00259-w

Internet

https://doi.org/10.1186/s40035-021-00259-w

Similar Items