Effects of Ospemifene on Drug Metabolism Mediated by Cytochrome P450 Enzymes in Humans in Vitro and in Vivo

Effects of Ospemifene on Drug Metabolism Mediated by Cytochrome P450 Enzymes in Humans in Vitro and in Vivo

The objective of these investigations was to determine the possible effects of the novel selective estrogen receptor modulator, ospemifene, on cytochrome P450 (CYP)-mediated drug metabolism. Ospemifene underwent testing for possible effects on CYP enzyme activity in human liver microsomes and in iso...

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Bibliographic Details
Main Authors: Mika Scheinin, Risto Lammintausta, Camilla Stjernschantz, Jouni Vuorinen, Pasi Tapanainen, Olavi Pelkonen, Terhi Lehtinen, Marita Kailajärvi, Jouko Uusitalo, Miia Turpeinen
Format: Article
Language:English
Published: MDPI AG 2013-07-01
Series:International Journal of Molecular Sciences
Subjects:
bupropion
CYP
omeprazole
selective estrogen receptor modulator
warfarin
Online Access:http://www.mdpi.com/1422-0067/14/7/14064

Internet

http://www.mdpi.com/1422-0067/14/7/14064

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