Expanded genetic screening in Caenorhabditis elegans identifies new regulators and an inhibitory role for NAD+ in axon regeneration

Expanded genetic screening in Caenorhabditis elegans identifies new regulators and an inhibitory role for NAD+ in axon regeneration

The mechanisms underlying axon regeneration in mature neurons are relevant to the understanding of normal nervous system maintenance and for developing therapeutic strategies for injury. Here, we report novel pathways in axon regeneration, identified by extending our previous function-based screen u...

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Bibliographic Details
Main Authors: Kyung Won Kim, Ngang Heok Tang, Christopher A Piggott, Matthew G Andrusiak, Seungmee Park, Ming Zhu, Naina Kurup, Salvatore J Cherra III, Zilu Wu, Andrew D Chisholm, Yishi Jin
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-11-01
Series:eLife
Subjects:
NMNAT
Kelch-domain protein
axon reconnection/fusion
membrane contact site (MCS)
phospholipid metabolic enzyme
membrane transporter
Online Access:https://elifesciences.org/articles/39756

Internet

https://elifesciences.org/articles/39756

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