AAV-mediated inhibition of ULK1 promotes axonal regeneration in the central nervous system in vitro and in vivo

AAV-mediated inhibition of ULK1 promotes axonal regeneration in the central nervous system in vitro and in vivo

Abstract Axonal damage is an early step in traumatic and neurodegenerative disorders of the central nervous system (CNS). Damaged axons are not able to regenerate sufficiently in the adult mammalian CNS, leading to permanent neurological deficits. Recently, we showed that inhibition of the autophagi...

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Bibliographic Details
Main Authors: Vinicius Toledo Ribas, Björn Friedhelm Vahsen, Lars Tatenhorst, Veronica Estrada, Vivian Dambeck, Raquel Alves Almeida, Mathias Bähr, Uwe Michel, Jan Christoph Koch, Hans Werner Müller, Paul Lingor
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-03503-3

Internet

https://doi.org/10.1038/s41419-021-03503-3

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