IKBKE, a prognostic factor preferentially expressed in mesenchymal glioblastoma, modulates tumoral immunosuppression through the STAT3/PD‐L1 pathway

IKBKE, a prognostic factor preferentially expressed in mesenchymal glioblastoma, modulates tumoral immunosuppression through the STAT3/PD‐L1 pathway

Abstract Inhibitor of nuclear factor kappa‐B kinase subunit epsilon (IKBKE) plays critical roles in the proliferation, invasion, and epithelial‐mesenchymal transition (EMT) of glioblastoma (GBM). However, as an immune response factor, few studies have focused on the role of IKBKE in the glioblastoma...

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Bibliographic Details
Main Authors: Li Yi, Gaochao Guo, Jiabo Li, Xiaoguang Fan, Tao Li, Luqing Tong, Peidong Liu, Xuya Wang, Feng Yuan, Shengping Yu, Qiang Huang, Xuejun Yang
Format: Article
Language:English
Published: Wiley 2020-07-01
Series:Clinical and Translational Medicine
Subjects:
glioma
IKBKE
immunosuppression
mesenchymal subtype
Online Access:https://doi.org/10.1002/ctm2.130

Internet

https://doi.org/10.1002/ctm2.130

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