Activation of the cardiac non-neuronal cholinergic system prevents the development of diabetes-associated cardiovascular complications

Activation of the cardiac non-neuronal cholinergic system prevents the development of diabetes-associated cardiovascular complications

Abstract Background Acetylcholine (ACh) plays a crucial role in the function of the heart. Recent evidence suggests that cardiomyocytes possess a non-neuronal cholinergic system (NNCS) that comprises of choline acetyltransferase (ChAT), choline transporter 1 (CHT1), vesicular acetylcholine transport...

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Bibliographic Details
Main Authors: Eng Leng Saw, James T. Pearson, Daryl O. Schwenke, Pujika Emani Munasinghe, Hirotsugu Tsuchimochi, Shruti Rawal, Sean Coffey, Philip Davis, Richard Bunton, Isabelle Van Hout, Yuko Kai, Michael J. A. Williams, Yoshihiko Kakinuma, Martin Fronius, Rajesh Katare
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Cardiovascular Diabetology
Subjects:
Non-neuronal cholinergic system
Acetylcholine
Diabetic heart disease
Glucose metabolism
Angiogenesis
Online Access:https://doi.org/10.1186/s12933-021-01231-8

Internet

https://doi.org/10.1186/s12933-021-01231-8

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